Microglia, key to understanding learning?

Fascinating article in New Scientist on the roles of neurons, astrocytes and microglia in the functioning of the brain.  Microglia were long though to lay dormant most of the time, only to spur into action in case of brain defects.  As so often, better data collection is revealing that these ‘elements’ play a much bigger role than thought:

As master multitaskers, microglia play many different roles. On the one hand, they are the brain’s emergency workers, swarming to injuries and clearing away the debris to allow healing to begin. On the other hand, during times of rest, they are its gardeners and caretakers, overseeing the growth of new neurons, cultivating new connections and pruning back regions that threaten to overgrow. They may also facilitate learning, by preparing the ground for memories to form.


Three elements of the brain ( (C) New Scientist)

Three elements of the brain ( (C) New Scientist)


Interestingly, there are hints that these microglia play an important role in memory and learning (as well as in diseases like Alzheimer’s and autism).  This role is just beginning to emerge.

For instance, besides pruning synapses, microglia cultivate their development, by secreting nutrients called growth factors that promote the sprouting of new neural connections. And once the synapse is formed, they may monitor and tweak the receptors that help pass messages between two neurons. Such changes, dubbed synaptic plasticity, fine-tune the communication across neural networks, and are thought to be a key mechanism for learning. Indeed, Tremblay has found signs of high microglial activity in the hippocampus – a brain region that is central to memory.

It will be fascinating to see how neuroscience will affect our theories of learning and pedagogies.  It makes me wonder whether neuroscience doesn’t deserve more attention in education courses, such as the MAODE?